Palladium-Catalyzed Modular Synthesis of Thiophene-Fused Polycyclic Aromatics via Sequential C–H Activation
A palladium-catalyzed Catellani-type [2+2+2] annulation reaction of aryl iodides, bromothiophenes, and norbornadiene, which proceeds via a tandem Heck coupling/double C-H bond activation and retro-Diels-Alder pathway to access thiophene-fused polyaromatics, is reported. The key feature of this protocol represents a NBD/NBE retaining annulation.
Authors
- Dongping Chen (ORCID: https://orcid.org/0009-0009-9848-2557)
- Yu Luo (ORCID: https://orcid.org/0000-0003-0614-6150)
- Ying Fu (ORCID: https://orcid.org/0000-0002-7312-1570)
- Zhengyin Du (ORCID: https://orcid.org/0000-0002-7124-8754)
- Hao Chen (ORCID: https://orcid.org/0000-0003-4137-2639)
- Jiajia Liu (ORCID: https://orcid.org/0000-0002-2718-2567)
Institutions
- Ministry of Education (IR)
- Northwest Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1021/acs.orglett.4c04597
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- National Natural Science Foundation of China