Metabolic effects of heterocyclic amines on insulin‑induced AKT phosphorylation and gluconeogenic gene expression are modified by N-acetyltransferase 2 genetic polymorphism
The findings suggest that NAT2 genetic polymorphism modifies HCA-induced insulin resistance and gluconeogenic gene expression, implying that individuals with rapid acetylator phenotype may be at greater risk of dysregulated glucose homeostasis following exposure to HCAs.
Authors
- Jonathan Y. Joh
- Kennedy M. Walls
- Kyung U. Hong (ORCID: https://orcid.org/0000-0001-6700-9470)
- David W. Hein (ORCID: https://orcid.org/0000-0003-3261-9775)
- M. Martínez (ORCID: https://orcid.org/0009-0005-9849-7901)
Institutions
- University of Louisville (US)
Publication Details
- Journal
- Pharmacogenetics and Genomics
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1097/fpc.0000000000000559
- Citations
- 2
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 1.87