Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
Sleep spindles predict long-term cognitive performance in AD. Sleep spindle and SOs can be predictive, non-invasive biomarkers for AD. Sleep may be one of the most important modifiable risk factors for AD progression. Sleep microarchitecture is a novel therapeutic target for preserving brain heath. Sleep physiology can provide novel therapeutic targets to slow AD progression.
Authors
- Selma Gillman
- Farida Dakterzada (ORCID: https://orcid.org/0000-0001-9720-7160)
- Arsenio Páez (ORCID: https://orcid.org/0000-0002-7984-514X)
- Ferrán Barbé (ORCID: https://orcid.org/0000-0002-2340-8928)
- Thien Thanh Dang‐Vu (ORCID: https://orcid.org/0000-0002-7235-2721)
- Anna Carnes (ORCID: https://orcid.org/0000-0003-2211-380X)
- Gerard Piñol Ripoll
- Shahla Bakian Dogaheh
Institutions
- Universitat de Lleida (ES)
- Hospital Universitari Arnau de Vilanova (ES)
- University of Oxford (GB)
- Hospital Universitari de Santa Maria (ES)
- Hospital Clínic de Barcelona (ES)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Instituto de Investigación Biomédica de Lleida (ES)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Concordia University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1002/alz.14424
- Citations
- 11
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 15.74
Funders
- Fundació la Marató de TV3
- Centres de Recerca de Catalunya
- European Commission
- Generalitat de Catalunya
- Fonds de recherche du Québec – Nature et technologies
- Instituto de Salud Carlos III
- European Regional Development Fund
- European Social Fund