Long-term Persistence of Moderate or Low Normal Testosterone Levels and Prostate Gland Volume in Men 35–45 Years Old

In our outpatient practice, we are increasingly seeing men aged from 35 to 45 years who have a long-term persistence of moderate or low normal testosterone levels. We aimed to investigate whether there is a link between long-term persistence of moderate or low normal testosterone levels and prostate volume. For the period from January 2013 to December 2015 in the Department of Andrology of “St. Sofia” Hospital we investigated 73 men aged 35 to 45 years with normal or elevated body mass index and long-term persistence of moderate or low testosterone levels. To compare our results, at the beginning of the study we formed a control group of 20 healthy men of the same age. The prostate volume was calculated by ultrasound. We obtained, within the reference range, significantly lower values for total testosterone (p < 0.001) and higher prostate volume (p < 0.001) in the 73 men we investigated compared to those in the control group. In some men at a young age, certain deviations in the normal secretion of testosterone occur, in parallel with an increase in total prostate volume, which differs significantly from the same indicator in their peers with a high normal level of testosterone. In most cases overweight or obesity were a prerequisite for young men to increase their prostate volume, but with a weaker correlation dependence than testosterone. Without going into cellular processes, we determined that long-term persistence of moderate or low normal testosterone levels, was a prerequisite for men aged between 35 and 45 years to increase their prostate volume.