Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the <scp>IL</scp>‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants
NC-EVs may modulate the production of specific cytokines and chemokines in human degenerate explants when the key pro-inflammatory cytokine IL-1β is present. Implementation of the technical EV-depleted controls in further studies is essential to robustly demonstrate that these effects are EV-mediated and not associated with other secreted factors co-isolated during EV-isolation.
Authors
- Joseph Snuggs (ORCID: https://orcid.org/0000-0002-0200-4596)
- Frances C. Bach (ORCID: https://orcid.org/0000-0002-4481-0051)
- Josette C. van Maanen (ORCID: https://orcid.org/0000-0003-0709-4735)
- Marca H. M. Wauben (ORCID: https://orcid.org/0000-0003-0360-0311)
- Marianna A. Tryfonidou (ORCID: https://orcid.org/0000-0002-2333-7162)
- Christine L. Le Maitre (ORCID: https://orcid.org/0000-0003-4489-7107)
- Keita Ito (ORCID: https://orcid.org/0000-0002-7372-4072)
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Eindhoven University of Technology (NL)
- University of Sheffield (GB)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1002/jsp2.70043
- Citations
- 6
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- International Society for the Study of the Lumbar Spine
- Dutch Arthritis Society
- Arthritis Society
- European Commission