The trend of phylogenetic and epitope variations of SARS-CoV-2 Omicron sub-lineages in Iran
Herein, the increased conservation of CD8<sup>+</sup> epitopes compared to CD4<sup>+</sup> and B cell epitopes is probably attributable to the shorter length of the peptides associated with CD8<sup>+</sup> epitopes. The high rate of T-cell epitopes conservation in non-spike proteins among different sub-lineages of the Omicron in this study highlighted the importance of cell-mediated immunity and suggested that non-spike proteins might be more attractive targets for future SARS-CoV-2 vaccines.
Authors
- Talat Mokhtari‐Azad (ORCID: https://orcid.org/0000-0002-6556-4072)
- Nazanin Zahra Shafiei Jandaghi (ORCID: https://orcid.org/0000-0002-6988-4321)
- Sevrin Zadheidar (ORCID: https://orcid.org/0000-0002-4326-4722)
- Kaveh Sadeghi (ORCID: https://orcid.org/0000-0003-4527-9167)
- Arghavan Zebardast (ORCID: https://orcid.org/0000-0002-8263-241X)
- Adel Abedi
- Ahmad Nejati (ORCID: https://orcid.org/0000-0003-2435-3065)
- Jila Yavarian (ORCID: https://orcid.org/0000-0003-3239-9397)
- Akram Sadat Ahmadi (ORCID: https://orcid.org/0000-0003-2219-4259)
- Mehdi Shabani (ORCID: https://orcid.org/0000-0003-3469-0727)
- Mohammad Hossein Najmi
- Monire Ghadirali
Institutions
- Tarbiat Modares University (IR)
- Shahid Beheshti University (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3389/fmicb.2024.1531712
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Tehran University of Medical Sciences and Health Services