The histone demethylase KDM5C enhances the sensitivity of acute myeloid leukemia cells to lenalidomide by stabilizing cereblon
This study provides a possible strategy for a combination treatment with MLN4924 and Len for leukemia.
Authors
- Qing Sun
- Guoqiang Xu (ORCID: https://orcid.org/0000-0002-4753-4769)
- Dan Cao (ORCID: https://orcid.org/0000-0002-3331-823X)
- Wen-Jun Yu
- Bing-Zong Li (ORCID: https://orcid.org/0000-0002-2732-9354)
- Liang Zhou (ORCID: https://orcid.org/0000-0003-0820-1520)
- Lu Zou (ORCID: https://orcid.org/0009-0008-2354-6002)
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s11658-025-00697-8
- Citations
- 3
- Primary Topic
- Protein Degradation and Inhibitors
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Science and Technology Program of Suzhou