A series of benzensulfonamide derivatives as new potent carbonic anhydrase IX and XII inhibitors
The best compound was <b>1i</b> that showed a low nanomolar range of K<sub>i</sub> value as CA inhibitor (K<sub>i</sub> = 9.4, 5.6 and 6.3 nM hCA II, IX and XII, respectively).
Authors
- Tiziano Tuccinardi (ORCID: https://orcid.org/0000-0002-6205-4069)
- Susanna Nencetti (ORCID: https://orcid.org/0000-0002-3547-7277)
- Giulio Poli (ORCID: https://orcid.org/0000-0002-8061-5632)
- Marco Macchia (ORCID: https://orcid.org/0000-0002-5565-2044)
- Miriana Di Stefano (ORCID: https://orcid.org/0000-0001-6727-5816)
- Elisa Nuti (ORCID: https://orcid.org/0000-0003-2669-5376)
- Lidia Ciccone (ORCID: https://orcid.org/0000-0002-2762-1929)
- Doretta Cuffaro (ORCID: https://orcid.org/0000-0002-8842-542X)
- Armando Rossello (ORCID: https://orcid.org/0000-0002-6795-8091)
- Claudiu T. Supuran
- Alessio Nocentini
- Elisabetta Orlandini
Institutions
- University of Pisa (IT)
- Piaggio (Italy) (IT)
- University of Florence (IT)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1080/17568919.2025.2453420
- Citations
- 1
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca