Preoperative Diffusion Tensor Imaging and Neurite Dispersion and Density Imaging in Isocitrate Dehydrogenase-Mutant Grade 2 and 3 Gliomas: Definition of Tumor-Related Epilepsy and Predictive Factors of Seizure Outcomes Based on a Single-Center Retros
DTI and NODDI tumor-derived quantitative parameters may define TRE and predict postoperative seizure outcomes in patients with IDH-mutant gliomas. Notably, DTI metrics were found to be independent predictors of postoperative seizure outcomes, while preoperative NODDI parameters correlated with seizure presentation. Further research is warranted to validate our findings and to better understand the underlying mechanisms driving TRE.
Authors
- Beatrice Bono (ORCID: https://orcid.org/0000-0002-6514-6188)
- Federico Pessina (ORCID: https://orcid.org/0000-0002-8717-4999)
- Matteo Simonelli (ORCID: https://orcid.org/0000-0002-5264-1251)
- Gaia Ninatti (ORCID: https://orcid.org/0000-0001-8207-1256)
- Pierina Navarria (ORCID: https://orcid.org/0000-0002-6913-1442)
- Angelo Dipasquale (ORCID: https://orcid.org/0000-0002-3326-8156)
- Giovanni Savini (ORCID: https://orcid.org/0000-0002-7133-429X)
- Andrea Franzini (ORCID: https://orcid.org/0000-0002-2031-4547)
- Asdhar Toro (ORCID: https://orcid.org/0000-0002-3987-1538)
- Luisa Bellu
- Zefferino Rossini (ORCID: https://orcid.org/0000-0002-1169-6846)
- Riccardo Levi (ORCID: https://orcid.org/0000-0001-9030-0071)
- Maria Pia Tropeano (ORCID: https://orcid.org/0000-0002-4653-1232)
- Letterio S. Politi (ORCID: https://orcid.org/0000-0002-6190-6688)
- Alessandro Grimi
- Marco Riva (ORCID: https://orcid.org/0000-0003-4643-6451)
Institutions
- Humanitas University (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Neurosurgery
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1227/neu.0000000000003365
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00