Type 1 Diabetes Risk Variants Reduce Beta Cell Function
These data suggest that rs1534422 and rs10517086 exert multiple insults on the β cell through excessive upregulation of <i>HNF1A</i> and induction of pro-inflammatory cytokines, and highlight their utility as prognostic markers of β cell function.
Authors
- Angus G. Jones (ORCID: https://orcid.org/0000-0002-0883-7599)
- Wiktoria Ratajczak (ORCID: https://orcid.org/0000-0001-7802-6911)
- Sarah D. Atkinson (ORCID: https://orcid.org/0000-0002-3208-8794)
- Catriona Kelly (ORCID: https://orcid.org/0000-0003-3740-4511)
Institutions
- University of Ulster (GB)
- University of Exeter (GB)
- Altnagelvin Area Hospital (GB)
Publication Details
- Journal
- Genes
- Published
- 2025-01-29
- DOI
- https://doi.org/10.3390/genes16020172
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department for the Economy
- Ulster University