Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway
Prostate cancer (PCa) is a highly common type of malignancy and affects millions of men in the world since it is easy to recur or emerge therapy resistance. Therefore, it is urgent to find novel treatments for PCa patients. In the current study, we found that tegaserod maleate (TM), an FDA-approved agent, inhibited proliferation, colony formation, migration as well as invasion, caused the arrest of the cell cycle, and promoted apoptosis of PCa cells in vitro. In addition, TM suppressed the tumor growth in the cell-derived xenograft (CDX) mouse model in vivo. Mechanistically, TM exerted anti-tumor effects via downregulating GLI2, and its downtream targets, thus inhibiting the sonic hedgehog (SHH) signaling pathway. In brief, our findings demonstrated that TM effectively inhibited the activities of PCa cells by suppressing the SHH signaling pathway and provided a potential new agent for the treatment of PCa.
Authors
- Shengdong Ge (ORCID: https://orcid.org/0000-0001-8187-9894)
- Mingkun Chen (ORCID: https://orcid.org/0000-0003-2544-302X)
- Donggen Zhong
- Zhanghui Chen (ORCID: https://orcid.org/0000-0002-6375-8797)
- Shan‐Chao Zhao (ORCID: https://orcid.org/0000-0002-1162-8077)
- Yongcheng Ren (ORCID: https://orcid.org/0000-0002-8673-4640)
- Ninghan Feng (ORCID: https://orcid.org/0000-0002-0892-6102)
- Yaying Hong (ORCID: https://orcid.org/0009-0004-5130-102X)
- Maoping Cai
- Yao Chen (ORCID: https://orcid.org/0000-0002-7120-0902)
- Yuan Liu (ORCID: https://orcid.org/0000-0001-9452-0442)
- Zhe-Sheng Chen
Institutions
- Jiangnan University (CN)
- St. John's University (US)
- Third Affiliated Hospital of Southern Medical University (CN)
- Central People's Hospital of Zhanjiang (CN)
- Nanfang Hospital (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Wuxi No.2 People's Hospital (CN)
- Wuxi People's Hospital (CN)
- Chinese People's Liberation Army (CN)
- Southern Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s10020-025-01080-1
- Citations
- 1
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Southern Medical University
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province