Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning
We discuss the role of oxidative stress and immune inflammation in the formation, progression, and stabilization of plaques by combining predictive models with analysis of single-cell data. It introduced novel insights into the mechanisms underlying carotid atherosclerosis formation and plaque progression and may assist in identifying potential therapeutic targets for their treatment.
Authors
- Mei Dong (ORCID: https://orcid.org/0000-0002-3515-4662)
- Yuyou Yang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Second Hospital of Shandong University (CN)
- Ministry of Education (BD)
- Qilu Hospital of Shandong University (CN)
- State Key Laboratory for Innovation and Transformation of Luobing Theory
Publication Details
- Journal
- Biology Direct
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s13062-025-00600-7
- Citations
- 5
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.99