Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning

We discuss the role of oxidative stress and immune inflammation in the formation, progression, and stabilization of plaques by combining predictive models with analysis of single-cell data. It introduced novel insights into the mechanisms underlying carotid atherosclerosis formation and plaque progression and may assist in identifying potential therapeutic targets for their treatment.

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Publication Details

Journal
Biology Direct
Published
2025-01-29
DOI
https://doi.org/10.1186/s13062-025-00600-7
Citations
5
Primary Topic
Atherosclerosis and Cardiovascular Diseases
Type
article
Field-Weighted Citation Impact
3.99
Controls
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article

Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning

Mei Dong, Yuyou Yang
5 citations
Biology Direct
Atherosclerosis and Cardiovascular Diseases
3.99
article

Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning

Mei Dong, Yuyou Yang
article en
5 citations

Abstract

We discuss the role of oxidative stress and immune inflammation in the formation, progression, and stabilization of plaques by combining predictive models with analysis of single-cell data. It introduced novel insights into the mechanisms underlying carotid atherosclerosis formation and plaque progression and may assist in identifying potential therapeutic targets for their treatment.

Biology DirectVol. 20(1)
Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Second Hospital of Shandong University (CN), Ministry of Education (BD), Qilu Hospital of Shandong University (CN), State Key Laboratory for Innovation and Transformation of Luobing Theory
Zero hunger
Openalex Percentile: Top 7%
Atherosclerosis and Cardiovascular Diseases
3.99
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Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning — Mei Dong, Yuyou Yang · Biology Direct (2025) | TGRS Research Map | TGRS