Prepartal Stress, Prepartal and Postpartal Hair Glucocorticoid Concentrations, and Symptoms of Postpartum Depression 3 Days and 12 Weeks After Delivery
Women with prepartal stress were at increased risk of experiencing PPD 12 weeks after delivery. Altered hair steroid levels (lower cortisone concentrations) as a proxy for altered HPA-AA further substantiated this association. Results suggest that 1) both prepartal stress and the suppression of HPA-AA appear to be involved in the development of PPD; 2) hair steroid analysis can be used to predict PPD; and 3) women with prepartal stressful life events may benefit from timely support and relief to decrease their risk of developing PPD.
Authors
- Serge Brand (ORCID: https://orcid.org/0000-0003-2175-2765)
- Gunther Meinlschmidt (ORCID: https://orcid.org/0000-0002-3488-193X)
- Jennifer Kurath (ORCID: https://orcid.org/0000-0002-6074-5325)
- Marion Tegethoff (ORCID: https://orcid.org/0000-0002-3911-9426)
- Dena Sadeghi Bahmani (ORCID: https://orcid.org/0000-0002-1301-5522)
- Thorsten Mikoteit (ORCID: https://orcid.org/0000-0003-2166-6330)
- Nicole Bürki
- Irène Hösli
Institutions
- Trier University of Applied Sciences (DE)
- University of Basel (CH)
- University Hospital of Basel (CH)
- Kermanshah University of Medical Sciences (IR)
- Hospital Base (CL)
- Psychiatry Baselland (CH)
- Schweizerische Ärztegesellschaft für Psycholytische Therapie (CH)
- Universitäre Psychiatrische Kliniken Basel (CH)
- Tehran University of Medical Sciences (IR)
- RWTH Aachen University (DE)
- Universität Trier (DE)
- Stanford University (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100454
- Citations
- 4
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Bundesministerium für Bildung und Forschung
- Hasler Stiftung
- Schweizerische Herzstiftung
- Gottfried und Julia Bangerter-Rhyner-Stiftung
- H. Lundbeck A/S
- HORIZON EUROPE Framework Programme
- Staatssekretariat für Bildung, Forschung und Innovation