The rise of NMR-integrated fragment-based drug discovery in China

Nuclear magnetic resonance (NMR) spectroscopy is an indispensable tool to probe weak protein-ligand interactions, which are key to the hit identification and hit-to-lead evolution in fragment-based drug discovery (FBDD). The integration of NMR technology in FBDD has facilitated the development of a diverse array of candidate compounds and FDA-approved drugs. Here, we summarized the rapid advancement and application of NMR techniques in contemporary China, which serves as a catalyst for the ongoing prosperousness of fragment-derived inhibitors against various targets.