[<sup>45</sup>Ti]Ti-HOPOs: Potential Complexes for the Development of <sup>45</sup>Ti PET Imaging Agents

Titanium-45 (<sup>45</sup>Ti) is a radionuclide with desirable physical characteristics for use in positron emission tomography (PET) imaging including a moderate half-life (3.08 h), decay by positron emission (85%), and low mean positron energy of 0.439 MeV. Despite these promising characteristics, the radiochemistry for <sup>45</sup>Ti including the development of suitable bifunctional chelators is relatively unexplored compared to that of other radiometals. This work investigated three hydroxypyridinone compounds, viz., 3,2,3-(LI-1,2-HOPO) or C8-HOPO, 3,3,3-(LI-1,2-HOPO) or C9-HOPO, 3,4,3-(LI-1,2-HOPO) or C10-HOPO as potential chelators for <sup>45</sup>Ti. Radiolabeling optimization, stability, and biodistribution results demonstrated C9-HOPO to be a promising chelator for <sup>45</sup>Ti. In vivo evaluation of the [<sup>45</sup>Ti]Ti-C9-HOPO complex indicated rapid clearance with no signs of decomplexation.

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Publication Details

Journal
ACS Omega
Published
2025-01-29
DOI
https://doi.org/10.1021/acsomega.4c05544
Citations
1
Primary Topic
Radiopharmaceutical Chemistry and Applications
Type
article
Field-Weighted Citation Impact
1.36

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article

[45Ti]Ti-HOPOs: Potential Complexes for the Development of 45Ti PET Imaging Agents

Gayan B. Wijeratne, Lynn C. Francesconi, Shefali Saini, Samith B. Jayawardana et al.
1 citations
ACS Omega
Radiopharmaceutical Chemistry and Applications
1.36
article

[45Ti]Ti-HOPOs: Potential Complexes for the Development of 45Ti PET Imaging Agents

Gayan B. Wijeratne, Lynn C. Francesconi, Shefali Saini, Samith B. Jayawardana, Jason S. Lewis, Michael D. Phipps, Suzanne E. Lapi, N. V. S. Dinesh K. Bhupathiraju, Melissa A. Deri
article en
1 citations

Abstract

Titanium-45 (<sup>45</sup>Ti) is a radionuclide with desirable physical characteristics for use in positron emission tomography (PET) imaging including a moderate half-life (3.08 h), decay by positron emission (85%), and low mean positron energy of 0.439 MeV. Despite these promising characteristics, the radiochemistry for <sup>45</sup>Ti including the development of suitable bifunctional chelators is relatively unexplored compared to that of other radiometals. This work investigated three hydroxypyridinone compounds, viz., 3,2,3-(LI-1,2-HOPO) or C8-HOPO, 3,3,3-(LI-1,2-HOPO) or C9-HOPO, 3,4,3-(LI-1,2-HOPO) or C10-HOPO as potential chelators for <sup>45</sup>Ti. Radiolabeling optimization, stability, and biodistribution results demonstrated C9-HOPO to be a promising chelator for <sup>45</sup>Ti. In vivo evaluation of the [<sup>45</sup>Ti]Ti-C9-HOPO complex indicated rapid clearance with no signs of decomplexation.

ACS OmegaVol. 10(7)
The Graduate Center, CUNY (US), Memorial Sloan Kettering Cancer Center (US), Lehman College (US), University of Alabama (US), City University of New York (US), University of Alabama at Birmingham (US), Hunter College (US), Laboratory of Molecular Genetics (PL), Division of Chemistry (US)
U.S. Department of Energy, National Cancer Institute
Openalex Percentile: Top 24%
Radiopharmaceutical Chemistry and Applications
1.36
DOIOpen Access PDFOpenAlex
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