Nanoparticle encapsulation enables systemic IGF-Trap delivery to inhibit intracerebral glioma growth
Our results identify the IGF-Trap as a potent inhibitor of intracerebral glioma growth and show that encapsulation in nanoparticles can improve delivery of biologics such as the IGF-Trap to the brain, thereby enhancing the therapeutic response.
Authors
- Julien Chambon (ORCID: https://orcid.org/0000-0001-8031-156X)
- Stéphane M. Gagné (ORCID: https://orcid.org/0000-0003-3476-2620)
- Janusz Rak (ORCID: https://orcid.org/0000-0002-2912-5566)
- Ichiro Nakano (ORCID: https://orcid.org/0000-0002-0916-3207)
- Alexandre Moquin
- Pnina Brodt (ORCID: https://orcid.org/0000-0002-8977-7179)
- Yasmine Benslimane
- Stéphanie Perrino
- Yinhsuan Michely Chen
- Orçun Haçarız
- Matthew Leibovitch (ORCID: https://orcid.org/0000-0002-9026-7141)
- Masakazu Hashimoto (ORCID: https://orcid.org/0000-0003-3184-9093)
- Qin Yang (ORCID: https://orcid.org/0000-0003-2527-1221)
- Brian Meehan (ORCID: https://orcid.org/0000-0002-7605-0149)
Institutions
- McGill University Health Centre (CA)
- SNC-Lavalin (Canada) (CA)
- University of Alabama at Birmingham (US)
- McGill University (CA)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1093/neuonc/noaf011
- Citations
- 5
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.13