The TB27 Transcriptomic Model for Predicting Mycobacterium tuberculosis Culture Conversion
We identified and validated a whole blood-based RNA signature (TB27) that demonstrates an excellent agreement between predicted and observed times to <i>M. tuberculosis</i> culture conversion during tuberculosis therapy. TB27 is a potential useful biomarker for anti-tuberculosis drug development and for prediction of treatment responses in clinical practice.
Authors
- Stefan H. E. Kaufmann (ORCID: https://orcid.org/0000-0001-9866-8268)
- Maren Schuhmann
- Korkut Avsar (ORCID: https://orcid.org/0000-0002-9483-7412)
- Patricia Sanchez‐Carballo (ORCID: https://orcid.org/0000-0003-1061-7023)
- Niklas Köhler (ORCID: https://orcid.org/0000-0002-1911-0379)
- Florian P. Maurer (ORCID: https://orcid.org/0000-0001-8353-5964)
- Thierry Rolling (ORCID: https://orcid.org/0000-0002-0277-5067)
- Dörte Nitschkowski (ORCID: https://orcid.org/0000-0002-5347-6403)
- Michael Höelscher (ORCID: https://orcid.org/0000-0002-7642-1835)
- Nika Zielinski
- Anna M. Mandalakas (ORCID: https://orcid.org/0000-0002-8091-3509)
- Ioana D. Olaru (ORCID: https://orcid.org/0000-0003-3392-9257)
- Jan Heyckendorf (ORCID: https://orcid.org/0000-0003-4203-8421)
- Gunar Günther (ORCID: https://orcid.org/0000-0002-2217-4322)
- Marius Müller (ORCID: https://orcid.org/0000-0003-4765-3933)
- Christoph Lange (ORCID: https://orcid.org/0000-0002-9691-4741)
- Dagmar Schaub
- Markus Unnewehr (ORCID: https://orcid.org/0000-0003-2841-9076)
- Barbara Kalsdorf
- Elena Terhalle
- Andrew R. DiNardo (ORCID: https://orcid.org/0000-0001-5990-6470)
- Maja Reimann (ORCID: https://orcid.org/0000-0002-2385-2287)
- Helmut J.F. Salzer (ORCID: https://orcid.org/0000-0003-0146-8310)
- Torsten Goldmann (ORCID: https://orcid.org/0000-0002-1621-560X)
- Elmira Ibraim
- Cristina Popa (ORCID: https://orcid.org/0000-0001-8191-926X)
- Andrea Rachow (ORCID: https://orcid.org/0000-0003-4729-3405)
- Victor Spînu
Institutions
- Roche (Switzerland) (CH)
- Johannes Kepler University of Linz (AT)
- Radboud University Nijmegen (NL)
- Witten/Herdecke University (DE)
- Universität Hamburg (DE)
- University of Konstanz (DE)
- University of Namibia (NA)
- University of Münster (DE)
- University Hospital of Bern (CH)
- Radboud University Medical Center (NL)
- Helmholtz Zentrum München (DE)
- LMU Klinikum (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Humboldt-Universität zu Berlin (DE)
- Institute for Advanced Study (US)
- Max Planck Institute for Infection Biology (DE)
- Katharinenhospital (DE)
- London School of Hygiene & Tropical Medicine (GB)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Hospital Schleswig-Holstein (DE)
- German Center for Infection Research (DE)
- Kepler Universitätsklinikum (AT)
- Institutul de Pneumoftiziologie "Marius Nasta" (RO)
- Asklepios Fachkliniken München-Gauting (DE)
- Research Center Borstel - Leibniz Lung Center (DE)
- German Center for Lung Research (DE)
- BioNTech (Germany) (DE)
- Klinikum Konstanz (DE)
- Texas Children's Hospital (US)
- Max Planck Institute for Multidisciplinary Sciences (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Ludwig-Maximilians-Universität München (DE)
- Texas A&M University (US)
- University of Lübeck (DE)
Publication Details
- Journal
- Pathogens and Immunity
- Published
- 2025-01-29
- DOI
- https://doi.org/10.20411/pai.v10i1.770
- Citations
- 4
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- Deutsches Zentrum für Infektionsforschung