Correlates of Protection Against Symptomatic COVID-19: The CORSER 5 Case–Control Study
In this case-control study, we provided evidence of correlates of protection of anti-SARS-CoV-2 IgG in saliva and serum, with saliva antibodies often outperforming serum. The finding that antibodies in saliva are a better correlate of protection than antibodies in serum may inform vaccine development by highlighting the importance of robust induction of mucosal immune responses. This study design may be used during future epidemics for the prompt assessment of correlates of protection.
Authors
- Stéphane Pelleau (ORCID: https://orcid.org/0000-0002-7070-2177)
- Simon Galmiche (ORCID: https://orcid.org/0000-0002-1691-1744)
- Olivia Chény
- Thomas Obadia
- Laura García (ORCID: https://orcid.org/0000-0001-8044-5365)
- Françoise Donnadieu
- Sandrine Fernandes Pellerin
- Sophie Vacant
- Hélène Laude (ORCID: https://orcid.org/0000-0002-3566-2763)
- Linda Sangari
- Arnaud Fontanet
- Michel Samson
- Christine Fanaud
- Laurence Arowas
- Maurine Delhaye
- Michaël White (ORCID: https://orcid.org/0000-0003-4530-8167)
- Nathalie Jolly
- Marek Fol (ORCID: https://orcid.org/0000-0002-8041-1920)
- Tiffany Charmet (ORCID: https://orcid.org/0000-0003-4012-4940)
- Emmanuel Roux (ORCID: https://orcid.org/0000-0001-8168-5643)
- Emma Bloch (ORCID: https://orcid.org/0009-0002-2227-9164)
- Ayla Zayoud
- Marie-Noëlle Ungeheuer
- Léopold Beeker
- Dorian Cheval
- Yanis Dahoumane
- Delal Ergen
- Mariem Essaidani
- Rémy Artus
Institutions
- Conservatoire National des Arts et Métiers (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Clinique Pasteur (FR)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-12-23
- DOI
- https://doi.org/10.1093/ofid/ofaf006
- Primary Topic
- COVID-19 and Mental Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00