Type 3 deiodinase activation mediated by the Shh/Gli1 axis promotes sepsis-induced metabolic dysregulation in skeletal muscles
The suppression of Dio3 restores tissue TH actions, attenuates proteolysis, and ameliorates anabolic resistance in the skeletal muscles of septic rats, thereby improving local metabolic homeostasis. Our results provide insights into the mechanisms of Dio3 reactivation and its critical role in local metabolic alterations induced by sepsis, while also suggesting novel targets aimed at ameliorating tissue-specific metabolic disorders.
Authors
- Tao Gao (ORCID: https://orcid.org/0000-0002-3687-8945)
- Yu Liu (ORCID: https://orcid.org/0009-0001-1986-5982)
- Jianfeng Duan (ORCID: https://orcid.org/0000-0003-2701-2709)
- Yun Xu (ORCID: https://orcid.org/0000-0001-5288-0319)
- Wenkui Yu (ORCID: https://orcid.org/0000-0003-1298-8928)
- Anqi Jiang
- Huimin Lu (ORCID: https://orcid.org/0000-0003-3638-2963)
- Yong Wang (ORCID: https://orcid.org/0000-0001-9928-280X)
- Xiaolan Lu
- Gang Wang (ORCID: https://orcid.org/0000-0003-0252-488X)
- Xiaoyao Li (ORCID: https://orcid.org/0000-0002-4600-1215)
Institutions
- Nanjing Drum Tower Hospital (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- State Key Laboratory of Pharmaceutical Biotechnology
- State Key Laboratory of Analytical Chemistry for Life Science (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Burns & Trauma
- Published
- 2024-10-18
- DOI
- https://doi.org/10.1093/burnst/tkae066
- Citations
- 3
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Nanjing University
- China International Medical Foundation
- Natural Science Foundation for Young Scientists of Shanxi Province
- Young Scientists Fund