Evaluation of drug delivery vehicles for improved transduction of oncolytic adenoviruses in solid tumor tissue
Out of the tested candidates, hyaluronidase showed the best potential to facilitate viral spread in tumor tissue and transduction of tumor cells. Therefore, hyaluronidase may be used as vehicle to improve clinical efficacy of oncolytic virotherapies.
Authors
- Sofie Ingvast
- Di Yu (ORCID: https://orcid.org/0000-0002-8636-0351)
- Erik Yngve
- Olle Korsgren (ORCID: https://orcid.org/0000-0002-8524-9547)
Institutions
- Uppsala University (SE)
Publication Details
- Journal
- Upsala Journal of Medical Sciences
- Published
- 2025-01-27
- DOI
- https://doi.org/10.48101/ujms.v130.11217
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sjöbergstiftelsen
- Cancerfonden
- Medical Research Council