Exploring the Impact of Music Frequency and Decibels on the Viability of Neuroblastoma Cancer Cells

This study examines the impact of music frequency on the viability of neuroblastoma cancer cells (SHSY5Y).SHSY5Y cells were exposed to music at varying frequencies and decibel levels, with "River Flows in You" by Yiruma (41 dB), "Brandenburg Concerto No.3" by Bach (62 dB), and "This is What it Feels Like" by Armin Van Buuren (86 dB) serving as the experimental stimuli.The cells' responses were analyzed after 24 and 48 hours of exposure, with cell viability assessed through automated cell counting devices using Acdine Orange and Propidium Iodide staining.Our findings show decreased viability of cancer cells exposed to high-frequency music.This result suggests a potential for high-frequency music to induce cancer cell death for cancer treatment.Conversely, low-frequency music increased the number of live cancer cells in the 2D culture model, indicating a music frequency effect on cell viability.These results contribute to the emerging field of bioacoustic oncology.Also, the frequency and intensity of the music could be leveraged for therapeutic purposes.This can offer a novel approach to cancer treatment with reduced side effects compared to traditional methods such as chemotherapy and radiotherapy.