Carnitine palmitoyltransferases in GtoPdb v.2024.4
The CPT1 enzymes convert long chain (greater than ∼C12) acyl-CoA molecules to acylcarnitine derivatives to facilitate their transport from the cytosol into the mitochondrial matrix via the carnitine/acylcarnitine carrier (CACT; SLC25A20). The acylcarnitines are converted back to acyl-CoA by CPT2 to support the fatty acid oxidation (FAO) cycle in the mitochondria. CPT1s are allosterically inhibited by malonyl-CoA.
Authors
- Núria Casals (ORCID: https://orcid.org/0000-0002-6719-4300)
- Rosalía Rodríguez‐Rodríguez (ORCID: https://orcid.org/0000-0002-6908-7197)
Institutions
- Universitat Internacional de Catalunya (ES)
Publication Details
- Journal
- IUPHAR/BPS Guide to Pharmacology CITE
- Published
- 2024-12-04
- DOI
- https://doi.org/10.2218/gtopdb/f1089/2024.4
- Citations
- 1
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.38