Hydrolases & Lipases in GtoPdb v.2024.4
Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; its inhibition is associated with decreased fat absorption. CES1 is present at lower levels in the gut than CES2 (P23141), but predominates in the liver, where it is responsible for the hydrolysis of many aliphatic, aromatic and steroid esters. Hormone-sensitive lipase is also a relatively non-selective esterase associated with steroid ester hydrolysis and triglyceride metabolism, particularly in adipose tissue. Endothelial lipase is secreted from endothelial cells and regulates circulating cholesterol in high density lipoproteins.
Authors
- Patrick Doherty (ORCID: https://orcid.org/0000-0002-0407-5689)
- Christopher Southan (ORCID: https://orcid.org/0000-0001-9580-0446)
- Neil D. Rawlings (ORCID: https://orcid.org/0000-0001-5557-7665)
- Christopher M. Overall (ORCID: https://orcid.org/0000-0001-5844-2731)
- David P. Fairlie (ORCID: https://orcid.org/0000-0002-7856-8566)
- Christopher J. Fowler (ORCID: https://orcid.org/0000-0002-6658-7874)
- S P H Alexander (ORCID: https://orcid.org/0000-0003-4417-497X)
- Anthony J. Turner
Institutions
- University of Leeds (GB)
- University of British Columbia (CA)
- University of Nottingham (GB)
- The University of Queensland (AU)
- King's College London (GB)
- Wellcome Sanger Institute (GB)
- University Hospital of Umeå (SE)
- University of Edinburgh (GB)
Publication Details
- Journal
- IUPHAR/BPS Guide to Pharmacology CITE
- Published
- 2024-12-04
- DOI
- https://doi.org/10.2218/gtopdb/f799/2024.4
- Citations
- 1
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.36