NEAT1 regulates BMSCs aging through disruption of FGF2 nuclear transport
Our findings position NEAT1 as a critical regulator of mitogenic protein networks that govern BMSC aging. Targeting NEAT1 might offer novel therapeutic strategies to rejuvenate aged BMSCs.
Authors
- Hengguo Zhang (ORCID: https://orcid.org/0000-0002-4438-8348)
- Jianguang Xu (ORCID: https://orcid.org/0000-0001-8773-1241)
- Zifei Wang (ORCID: https://orcid.org/0000-0001-7298-596X)
- Fei Xu (ORCID: https://orcid.org/0000-0001-8543-6636)
- Wansu Sun (ORCID: https://orcid.org/0000-0002-9256-2654)
- Ruikang K. Wang (ORCID: https://orcid.org/0000-0001-5169-8822)
- Wenhao Zhang (ORCID: https://orcid.org/0009-0000-6298-0225)
- Qing Kenneth Wang (ORCID: https://orcid.org/0000-0002-2235-6572)
- Yulong Zhang (ORCID: https://orcid.org/0000-0003-1459-2054)
- Yuqiang Sun (ORCID: https://orcid.org/0000-0002-7277-5775)
- Yuxuan Xie (ORCID: https://orcid.org/0009-0006-8087-6337)
- Wu Xing (ORCID: https://orcid.org/0000-0002-5371-6198)
- Sensen Yu
- Wenyu Zhen
- Siyu Jin
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s13287-025-04156-1
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Anhui Medical University
- Natural Science Foundation of Anhui Province