E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration
Taken together, our results support the hypothesis that the CNF1 toxin from E. coli plays an active role in colorectal carcinogenesis. Altogether, these findings not only add new knowledge to the contribution of bacterial toxins to CRC, but also pave the way to the implementation of current screening programs and preventive strategies.
Authors
- Zaira Maroccia (ORCID: https://orcid.org/0000-0002-0659-3076)
- Alessandro Sgambato (ORCID: https://orcid.org/0000-0002-9487-4563)
- Mauro Biffoni (ORCID: https://orcid.org/0000-0002-1304-9060)
- Alessia Fiore
- Massimo Spada
- Roberta De Angelis (ORCID: https://orcid.org/0000-0001-7787-3043)
- Filippo Torrigiani (ORCID: https://orcid.org/0000-0002-2601-684X)
- Paola Matarrese (ORCID: https://orcid.org/0000-0001-5477-3752)
- Olimpia Vincentini (ORCID: https://orcid.org/0000-0002-4137-4135)
- Simona Donati (ORCID: https://orcid.org/0000-0001-5214-9913)
- Laura Bracci
- Maria Carollo (ORCID: https://orcid.org/0000-0002-4616-4145)
- Concetta Panebianco (ORCID: https://orcid.org/0000-0003-2819-3505)
- Marco Guidotti (ORCID: https://orcid.org/0000-0001-8932-9141)
- Francesca Marcon (ORCID: https://orcid.org/0000-0002-0431-8310)
- Federica Moschella (ORCID: https://orcid.org/0000-0002-1965-6523)
- Francesca Carlini (ORCID: https://orcid.org/0000-0002-2409-6284)
- Sara Travaglione (ORCID: https://orcid.org/0000-0002-2816-0490)
- Alessia Fabbri
- Antonella Sistigu (ORCID: https://orcid.org/0000-0002-2528-1238)
- Donatella Pietraforte (ORCID: https://orcid.org/0000-0001-6370-912X)
- Lucrezia Gambardella (ORCID: https://orcid.org/0000-0003-3899-5958)
- Filomena Colella (ORCID: https://orcid.org/0000-0002-7088-6551)
- Maria Grazia Tozzi (ORCID: https://orcid.org/0000-0002-1075-7096)
- Elena Germinario (ORCID: https://orcid.org/0000-0003-1312-7476)
- Donatella Lucchetti (ORCID: https://orcid.org/0000-0001-8147-0079)
- Susanna Tomasoni (ORCID: https://orcid.org/0000-0002-7212-2512)
- Maria Cristina Quattrini (ORCID: https://orcid.org/0000-0001-6631-115X)
- Ranieri Verin (ORCID: https://orcid.org/0000-0001-9366-5682)
- Francesca Spadaro (ORCID: https://orcid.org/0000-0002-6610-350X)
- Valerio Pazienza (ORCID: https://orcid.org/0000-0002-3492-1153)
- Agostina Pietrantoni (ORCID: https://orcid.org/0000-0002-1121-4464)
- Gabriella Rainaldi (ORCID: https://orcid.org/0000-0001-7213-6853)
- Daniele Macchia
- Omar Leoni
- Ilenia Laterza
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Padua (IT)
- Istituto Superiore di Sanità (IT)
- Casa Sollievo della Sofferenza (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s13046-024-03271-w
- Citations
- 15
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 12.09
Funders
- Associazione Italiana per la Ricerca sul Cancro