Species- and strain-specific microbial modulation of interferon, innate immunity, and epithelial barrier in 2D air–liquid interface respiratory epithelial cultures
Microbial colonization differentially stimulates host gene expression with variations observed across phylogenetically diverse microbes and across different strains of the same species. Our study provides a foundation for understanding how the respiratory microbiome's biodiversity affects epithelial, and particularly antiviral, innate immunity.
Authors
- Mian Horvath (ORCID: https://orcid.org/0000-0003-1878-8644)
- José Luís Fachi (ORCID: https://orcid.org/0000-0002-1035-5193)
- Peter Paul Yu (ORCID: https://orcid.org/0000-0002-7238-1557)
- Andrew Salner (ORCID: https://orcid.org/0000-0002-3145-2953)
- Diana Cadena Castaneda (ORCID: https://orcid.org/0000-0002-2713-7192)
- Karolina Palucka (ORCID: https://orcid.org/0000-0002-1600-6066)
- Ryan Caldwell (ORCID: https://orcid.org/0000-0002-2348-6352)
- Julia Oh (ORCID: https://orcid.org/0000-0002-5534-7023)
- Marco Colonna (ORCID: https://orcid.org/0000-0001-5222-4987)
- Ruoyu Yang (ORCID: https://orcid.org/0000-0002-8815-4439)
- Megan Callender
- Zoe Scholar
- Blanda Di Luccia (ORCID: https://orcid.org/0000-0002-0137-953X)
- Anita Y. Voigt (ORCID: https://orcid.org/0000-0002-6794-0385)
- Elizabeth Aiken
Institutions
- Hartford Hospital (US)
- Duke University (US)
- Washington University in St. Louis (US)
- Jackson Laboratory (US)
- Hartford Financial Services (United States)
- UConn Health (US)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-01-29
- DOI
- https://doi.org/10.1186/s12915-025-02129-7
- Citations
- 3
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- National Institutes of Health