DEVELOPMENT OF HYPOTENSION AND BRADYCARDIA UNDER THE EFFECT OF PROPOFOL ON RATS WITH DIABETES MELLITUS

Propofol is an anesthetic that is widely used in clinical practice and recommended for patients with diabetes mellitus because it produces less complications compared to other anesthetics. Furthermore, surgical procedures may result in the develop ment of hypoxia. The aim of our study was to investigate the effect of propofol on systemic vascular contractility, mean arterial pressure (MAP), and heart rate (HR) under normoxia and hypoxia in rats with streptozotocin-induced type 1 diabetes (DM). The effect of propofol (10-9 - 3×10-4 mol/l) on the aortic segments of rats with DM caused a significant dose-dependent relaxation compared with control rats. A single intravenous injection of propofol caused no alterations in the hemodynamics of control rats. Still, it induced a dosedependent reduction in HR and MAP in rats with DM under the maximum dose of the study at normoxia. The administration of propofol under hypoxic hypoxia (HH) caused no decrease in MAP but reduced HR in control rats. In rats with diabetes, propofol treatment under HH induced a gradual decrease in MAP and HR, and the reduction in HR was significantly larger than in control rats. HH, which was exposed to animals after propofol administration, produced a significant decrease in MAP compared to rats without the treatment in both groups of rats. HH caused no changes in HR in control rats regardless of pretreatment with propofol but in rats with DM after propofol administration, hypoxic exposure induced a significant decrease in HR, which was accompanied by a rapid drop in MAP and bradycardia for 37.5% of the animals. Therefore, propofol caused no alterations in hemodynamic parameters in healthy rats under normoxia but reduced HR and MAP in rats with DM. Especially this effect was manifested under hypoxia. The data obtained can help to develop guidelines for propofol use in patients with DM.