Gut Microbiome and Metabolome Changes in Chronic Low Back Pain Patients With Vertebral Bone Marrow Lesions
This study sheds light on the intricate relationship between the disturbed gut ecosystem, serum metabolites, and FR in chronic LBP. Dysbiosis in the gut microbiome may contribute to altered BCAA degradation, subsequently promoting BM-MSCs adipogenesis and FR. Understanding these interactions provides insights for targeted therapeutic strategies to mitigate chronic LBP associated with FR by restoring gut microbial balance and modulating serum metabolite profiles.
Authors
- Sidong Yang (ORCID: https://orcid.org/0000-0003-2342-4714)
- Yang Cao (ORCID: https://orcid.org/0000-0002-0058-614X)
- Wenyuan Ding (ORCID: https://orcid.org/0000-0002-7257-4316)
- Ashish D. Diwan (ORCID: https://orcid.org/0000-0003-1037-8421)
- Abhirup Das (ORCID: https://orcid.org/0000-0003-1866-457X)
- Ji Tu (ORCID: https://orcid.org/0000-0001-7933-3016)
- Jun Zou (ORCID: https://orcid.org/0000-0003-0443-3156)
- Xupeng Bai (ORCID: https://orcid.org/0000-0001-5393-1405)
- Jinjian Zheng (ORCID: https://orcid.org/0000-0003-0865-815X)
- Kaitao Lai (ORCID: https://orcid.org/0000-0002-9420-9352)
- Xiaotao Jiang (ORCID: https://orcid.org/0000-0003-1804-5314)
- Yan Qi (ORCID: https://orcid.org/0000-0001-9542-5607)
- Wentian Li (ORCID: https://orcid.org/0000-0001-7268-557X)
- Zhaomin Zheng
Institutions
- Hebei Medical University (CN)
- The University of Sydney (AU)
- Union Hospital (HK)
- Royal Adelaide Hospital (AU)
- Charles Sturt University (AU)
- Sun Yat-sen University (CN)
- The University of Queensland (AU)
- Sutherland Hospital (AU)
- Concord Repatriation General Hospital (AU)
- Nepean Hospital (AU)
- UNSW Sydney (AU)
- Soochow University (CN)
- Third Hospital of Hebei Medical University (CN)
- St George Hospital (AU)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Anzac Research Institute (AU)
- First Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Huazhong University of Science and Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/jsp2.70042
- Citations
- 3
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.42