Characterization of SARS‐CoV‐2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection
Although myogenic cells express the genes required for SARS-CoV-2 entry and can be directly infected, there was no evident relationship between viral transcript levels and manifestations of atrophy, either in vitro or in vivo. Our results do not support direct myofibre infection by SARS-CoV-2 as a likely cause of atrophy in COVID-19.
Authors
- Eva Kaufmann (ORCID: https://orcid.org/0000-0001-7965-9200)
- Ekaterina Gusev
- Maziar Divangahi (ORCID: https://orcid.org/0000-0002-1254-6110)
- Feng‐Xia Liang (ORCID: https://orcid.org/0000-0003-0037-4590)
- Qutayba Hamid (ORCID: https://orcid.org/0000-0002-1107-190X)
- Basil J. Petrof (ORCID: https://orcid.org/0000-0002-7952-0222)
- Salyan Bhattarai (ORCID: https://orcid.org/0000-0002-6553-0286)
- Yumin Zheng (ORCID: https://orcid.org/0009-0008-4580-5247)
- Jun Ding
Institutions
- Queen's University (CA)
- McGill University Health Centre (CA)
- University of Sharjah (AE)
- McGill University (CA)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/jcsm.13705
- Citations
- 2
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Canadian Institutes of Health Research