Predictors of pulmonary hypertension in the subacute period of myocardial infarction in young and middle-aged males

Aim . To identify predictors of the development of pulmonary hypertension (PH) in the subacute period of myocardial infarction (MI) in young and middle-aged males to improve preventive measures. Materials and methods. We studied the results of treatment of male patients aged 32–60 years with a verified diagnosis of MI. Based on echocardiography findings and detection of PH at the end of the third week of MI, the patients were divided into the study group (patients with PH) and the comparison group (patients with a normal pressure in the pulmonary artery). In the studied groups, a comparative assessment of various parameters was performed, and an analysis of the risks of developing PH using the Pearson’s chi-squared test was conducted. Results . We found that the risk of developing PH in the subacute period of MI was significantly affected by certain parameters of peripheral hemodynamics, the presence of bradycardia, and the calculated value of total pulmonary resistance. The main parameters of the lipid profile were found to be significant predictors of PH in the subacute period of MI, along with some parameters of electrolyte metabolism (sodium and magnesium in the first 48 hours of MI, potassium and calcium at the end of the third week of the disease). We established the presence of a reliable relationship between several parameters of the structural and functional state of the myocardium both in the first 48 hours of MI and the end of the third week of the disease with the risk of developing PH in the subacute period of MI. Conclusion . The identified predictors make it possible to determine patients with MI who are at an increased risk of PH to timely diagnose and treat the disease and improve the prognosis.