HYQTD Drug-containing Serum Alleviates H2O2-induced Endothelial Oxidative Damage by Increasing Mitochondrial ATP Synthesis and Inhibiting ROS
We demonstrated that HYQTD-DS attenuated oxidative stress, improved mitochondrial function, and up-regulated mitochondrial ATP synthesis by activating SIRT1/PGC- 1α/Nrf2 pathway-induced mitochondrial biogenesis and its downstream NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDV2).
Authors
- Xue Leng (ORCID: https://orcid.org/0000-0001-6173-5981)
- Lianqun Jia (ORCID: https://orcid.org/0000-0003-0923-6987)
- Lijuan Chen (ORCID: https://orcid.org/0000-0003-2392-1948)
- Dongchao Yuan
- Ying Du
- Bin Lv (ORCID: https://orcid.org/0000-0002-4368-0232)
- Jin Wu
- M. S. Yang
- Yeyu Zhao
Institutions
- Liaoning University of Traditional Chinese Medicine (CN)
- University of South China (CN)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.2174/0113892010333981250122003904
- Citations
- 1
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.81