Resting-state connectivity and task-based cortical response in post-stroke executive dysfunction: A fNIRS study
Our study highlights the importance of including the parietal cortex in fNIRS studies of PSED to obtain a comprehensive understanding of EF deficits. From the investigation of task-based cortical response, PSED patients exhibited different patterns of FC despite reduced task-based cortical activation: compensatory cross-hemispheric hyperconnectivity during the Stroop task, while maladaptive within-frontal and between IPL and frontopolar hypoconnectivity during the 1-back task. Incorporating the insights gained from our study, future research can explore multi-targeted neuromodulation strategies that address frontal and parietal cortices may be more effective in improving cognitive outcomes in stroke survivors.
Authors
- Zhiqing Zhou (ORCID: https://orcid.org/0000-0002-8635-8438)
- Songmei Chen (ORCID: https://orcid.org/0000-0002-9961-2546)
- Chunlei Shan (ORCID: https://orcid.org/0000-0002-2742-1281)
- Jingjing Zhang (ORCID: https://orcid.org/0009-0005-2823-6255)
- Xiaolin Zhang (ORCID: https://orcid.org/0000-0002-9875-1931)
- Xiaowen Wang (ORCID: https://orcid.org/0009-0003-4906-6297)
- Deng Liu
- Xixi Chen (ORCID: https://orcid.org/0000-0003-3992-6911)
- K. B. Chong
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Tongren Hospital (CN)
- Western Digital (China) (CN)
- Shanghai Sunshine Rehabilitation Center (CN)
Publication Details
- Journal
- Neuroimage Reports
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.ynirp.2025.100236
- Citations
- 2
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.86
Funders
- National Natural Science Foundation of China