Development of Progressively Earth-Independent Medical Operations to Enable NASA Exploration Missions

<b>Introduction</b> -The National Aeronautics and Space Administration's (NASA's) transition from operations in low-Earth orbit to long-duration missions to the Moon and Mars necessitates the development of progressively Earth-independent medical operations (EIMO) to support crews and reduce overall mission risk. Previous work has defined and laid the foundation for EIMO, but further development of the concept is required to prepare for future exploration missions. <b>Methods</b> -NASA's Exploration Medical Capability element organized a series of 5 technical interchange meetings from 2023 to 2024, which included internal (NASA) and external subject-matter experts in human spaceflight, health technology, and austere medicine to create a framework for developing the technologies and procedures necessary to maintain human health and performance in a progressively Earth-independent fashion. <b>Results</b> -The EIMO technical interchange meetings provided a forum for a field of experts and stakeholders to better understand gaps between current approaches to medical care in low-Earth orbit and the innovations needed to maintain the health and performance of astronauts on long-duration deep-space missions. These discussions were recorded, analyzed, and collated into reports that can inform the maturation of EIMO concepts. <b>Conclusions</b> -Multidisciplinary input from experts with experience in human spaceflight, health technology, and austere medicine is critical when planning for long-duration exploration missions. Innovations such as probabilistic risk assessment tools, extended reality devices, and advanced clinical artificial intelligence capabilities have been identified as high-value targets that can enhance inflight medical autonomy while maintaining appropriate workload balance and crew safety. By further developing the EIMO paradigm, NASA aims to identify areas of future work, research, and collaboration to reduce overall risk on future human spaceflight missions into deep space.