Systemic Changes in Early Pregnancy in the Mare: An Integrated Proteomic Analysis of Blood Plasma, Histotroph, and Yolk Sac Fluid at Day 14 Post‐Ovulation

These analyses identified consistent systemic changes in the mare's proteome that indicate a profound and specific immune response to early pregnancy, which appears to precede the systemic endocrine response to pregnancy. Integrated pathway analysis suggests that embryo-maternal interactions in early pregnancy may mimic elements of the virus-host interaction to modulate the maternal immune response. Transthyretin (TTR) and uteroglobin (SCGB1A1) were respectively down- and upregulated in plasma while also present in uterine fluid, and are proposed to be key proteins in early pregnancy establishment. These findings contribute significantly to our knowledge of early pregnancy in the mare and identify potential new avenues for developing clinical approaches to reduce early embryo loss.

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Journal
PROTEOMICS - CLINICAL APPLICATIONS
Published
2025-01-27
DOI
https://doi.org/10.1002/prca.202400095
Primary Topic
Reproductive Physiology in Livestock
Type
article
Field-Weighted Citation Impact
0.00

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article

Systemic Changes in Early Pregnancy in the Mare: An Integrated Proteomic Analysis of Blood Plasma, Histotroph, and Yolk Sac Fluid at Day 14 Post‐Ovulation

Tom A. E. Stout, Zamira Gibb, Tharangani R. W. Perera, Alecia Sheridan et al.
PROTEOMICS - CLINICAL APPLICATIONS
Reproductive Physiology in Livestock
article

Systemic Changes in Early Pregnancy in the Mare: An Integrated Proteomic Analysis of Blood Plasma, Histotroph, and Yolk Sac Fluid at Day 14 Post‐Ovulation

Tom A. E. Stout, Zamira Gibb, Tharangani R. W. Perera, Alecia Sheridan, Marta de Ruijter‐Villani, Brett Nixon, Aleona Swegen, David A. Skerrett‐Byrne
article en

Abstract

These analyses identified consistent systemic changes in the mare's proteome that indicate a profound and specific immune response to early pregnancy, which appears to precede the systemic endocrine response to pregnancy. Integrated pathway analysis suggests that embryo-maternal interactions in early pregnancy may mimic elements of the virus-host interaction to modulate the maternal immune response. Transthyretin (TTR) and uteroglobin (SCGB1A1) were respectively down- and upregulated in plasma while also present in uterine fluid, and are proposed to be key proteins in early pregnancy establishment. These findings contribute significantly to our knowledge of early pregnancy in the mare and identify potential new avenues for developing clinical approaches to reduce early embryo loss.

PROTEOMICS - CLINICAL APPLICATIONSVol. 19(2)
Utrecht University (NL), Helmholtz Zentrum München (DE), Hunter Medical Research Institute (AU), Deutsches Diabetes-Zentrum e.V. (DE), German Center for Diabetes Research (DE), Heinrich Heine University Düsseldorf (DE), University of Newcastle Australia (AU)
Agrifutures Australia, Australian Research Council
Openalex Percentile: Top 98%
Reproductive Physiology in Livestock
DOIOpen Access PDFOpenAlex
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