Testosterone Modulation of Muscle Transcriptomic Profile During Lifestyle Therapy in Older Men with Obesity and Hypogonadism
The addition of TRT to lifestyle therapy mitigates the weight-loss-induced reduction of muscle mass and BMD via countering the weight-loss-induced downregulation of genes involved in muscle and bone anabolism.
Authors
- Dennis T. Villareal (ORCID: https://orcid.org/0000-0003-1365-7960)
- Benny Abraham Kaipparettu (ORCID: https://orcid.org/0000-0003-3444-4307)
- Alessandra Celli (ORCID: https://orcid.org/0009-0000-2186-0892)
- Reina Armamento‐Villareal (ORCID: https://orcid.org/0000-0002-5956-4922)
- Clifford Qualls (ORCID: https://orcid.org/0000-0002-9110-3181)
- Nicola Napoli (ORCID: https://orcid.org/0000-0002-3091-8205)
- Yoann Barnouin (ORCID: https://orcid.org/0000-0002-3497-9099)
- Georgia Colleluori (ORCID: https://orcid.org/0000-0002-4908-9873)
- Tagari Samanta (ORCID: https://orcid.org/0000-0003-2825-6801)
- Viola Viola (ORCID: https://orcid.org/0000-0002-4557-816X)
- Nam Nguyen (ORCID: https://orcid.org/0009-0009-5545-090X)
- Maria Liza Duremdes Nava
Institutions
- Michael E. DeBakey VA Medical Center (US)
- University of New Mexico (US)
- Baylor College of Medicine (US)
- Washington University in St. Louis (US)
- Campus Bio Medico University Hospital (IT)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/jcsm.13697
- Citations
- 3
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 3.45
Funders
- U.S. Department of Veterans Affairs
- Clinical Science Research and Development