Intestinal <i>Bacteroides</i> drives glioma progression by regulating CD8+ T cell tumor infiltration
Taken together, these findings establish, for the first time, a mechanistic relationship between Bacteroides in the intestinal microbiome and NF1-LGG pathobiology, suggesting both future predictive risk assessment strategies and therapeutic opportunities.
Authors
- Lawrence A. Schriefer (ORCID: https://orcid.org/0000-0001-6865-8683)
- Stephanie L Bozeman
- Rachel Rodgers (ORCID: https://orcid.org/0000-0001-7787-0491)
- Rui Mu (ORCID: https://orcid.org/0009-0005-4221-4159)
- Xuanwei Li
- David H. Gutmann (ORCID: https://orcid.org/0000-0002-3127-5045)
- Somya Aggarwal (ORCID: https://orcid.org/0000-0002-4586-9485)
- Danielle E. Campbell (ORCID: https://orcid.org/0000-0002-4072-3874)
- Megan T. Baldridge (ORCID: https://orcid.org/0000-0002-7030-6131)
- Jit Chatterjee (ORCID: https://orcid.org/0000-0002-2444-9748)
- Megan Ouyang
- Xuanhe Qi
- Talia Eligator
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1093/neuonc/noaf024
- Citations
- 10
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 16.25