Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease
Rapid eye movement latency (REML) may be a potential marker for Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD) pathogenesis. Prolonged REML was associated with higher amyloid beta (Aβ) burden, phosphorylated tau-181 (p-tau181), and lower brain-derived neurotrophic factor (BDNF) levels. Intervention trial is needed to determine if targeting REML can modify AD/ADRD risk. Slow-wave sleep was not associated with AD/ADRD biomarkers.
Authors
- Yue Leng (ORCID: https://orcid.org/0000-0001-5826-4031)
- Jiong Chen (ORCID: https://orcid.org/0000-0001-9389-520X)
- Jiangli Jin (ORCID: https://orcid.org/0000-0002-1704-7732)
- Brendan P. Lucey (ORCID: https://orcid.org/0000-0001-5400-825X)
- Kristine S. Yaffe (ORCID: https://orcid.org/0000-0003-0919-3825)
- Clémence Cavaillès (ORCID: https://orcid.org/0000-0002-8443-2307)
- Joseph R. Winer (ORCID: https://orcid.org/0000-0003-4069-3158)
- Laura Stankeviciute (ORCID: https://orcid.org/0000-0002-6601-3336)
- Dantao Peng (ORCID: https://orcid.org/0000-0001-8038-3192)
- Song Gao (ORCID: https://orcid.org/0000-0003-2585-6748)
- Xiao Zhou (ORCID: https://orcid.org/0009-0008-1132-6408)
Institutions
- University of California, San Francisco (US)
- Peking University (CN)
- Washington University in St. Louis (US)
- China-Japan Friendship Hospital (CN)
- Pasqual Maragall Foundation (ES)
- Barcelonaβeta Brain Research Center (ES)
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University (CN)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/alz.14495
- Citations
- 23
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 32.92
Funders
- Ministry of Science and Technology of the People's Republic of China
- National Health Commission of the People's Republic of China