Mediation of modifiable risk factors in two multidomain dementia prevention trials
There is no mediating role of risk factor change in the effects of multidomain interventions on dementia incidence in two large dementia prevention randomized controlled trials. The lack of effect of the interventions on risk factors explains the absence of impact on dementia. Counteracting mediators do not explain the lack of effect of the interventions on dementia. A small effect of the interventions on blood pressure did not translate into a lower dementia incidence.
Authors
- Nicola Coley (ORCID: https://orcid.org/0000-0002-1671-824X)
- Edo Richard (ORCID: https://orcid.org/0000-0002-7250-3390)
- Jason Shourik
- Jan Willem van Dalen (ORCID: https://orcid.org/0000-0002-3439-8841)
- Marieke P. Hoevenaar‐Blom (ORCID: https://orcid.org/0000-0002-6760-5149)
- Willem A. van Gool (ORCID: https://orcid.org/0000-0003-3174-8233)
- Eric Moll van Charante
- Sandrine Andrieu
Institutions
- Université Toulouse III - Paul Sabatier (FR)
- Radboud University Nijmegen (NL)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Radboud University Medical Center (NL)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- GGD Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/alz.14557
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Les Laboratories Pierre Fabre
- Fondation Vaincre Alzheimer
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- ZonMw
- Centre Hospitalier Universitaire de Toulouse
- Alzheimer Nederland
- Avid Radiopharmaceuticals