Nuclear Calcium Signaling in D1 Receptor–Expressing Neurons of the Nucleus Accumbens Regulates Molecular, Cellular, and Behavioral Adaptations to Cocaine
Our study unravels the dynamics and roles of cocaine-induced nuclear calcium signaling increases in D1R-MSNs on molecular, cellular, and behavioral adaptations to cocaine and represents a significant breakthrough because it could contribute to the development of innovative strategies with therapeutic potential to alleviate addiction symptoms.
Authors
- Enrica Montalban (ORCID: https://orcid.org/0000-0001-7625-7820)
- Estefani Saint‐Jour (ORCID: https://orcid.org/0000-0002-0947-6801)
- Katleen Pinchaud
- Lisa Huet
- Anna M. Hagenston (ORCID: https://orcid.org/0000-0001-7747-5336)
- Nicolas Gervasi (ORCID: https://orcid.org/0000-0002-1924-2443)
- Mélanie Marias
- Jocelyne Caboche (ORCID: https://orcid.org/0000-0003-4742-7055)
- Peter Vanhoutte (ORCID: https://orcid.org/0000-0001-9236-4888)
- Thomas Lissek (ORCID: https://orcid.org/0000-0003-4748-5474)
- Marie‐Charlotte Allichon
- Andry Andrianarivelo (ORCID: https://orcid.org/0000-0002-6369-4201)
- Hilmar Bading (ORCID: https://orcid.org/0000-0003-0258-4348)
- Claire Martin (ORCID: https://orcid.org/0000-0001-5340-8323)
- Nicolas Heck (ORCID: https://orcid.org/0000-0002-5754-8873)
- Sandrine Bétuing (ORCID: https://orcid.org/0000-0002-4733-6922)
- Faustine Arrivet
- Adèle Vilette
- Aisha Ravenhorst
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Collège de France (FR)
- Université Paris Cité (FR)
- Heidelberg University (DE)
- Université Paris Sciences et Lettres (FR)
- Sorbonne Université (FR)
- Centre National pour la Recherche Scientifique et Technique (CNRST) (MA)
- Institut de Biologie Paris-Seine (FR)
- Centre Interdisciplinaire de Recherche en Biologie (FR)
- Center for Neurosciences (US)
- Unit of Functional and Adaptive Biology (FR)
Publication Details
- Journal
- Biological Psychiatry
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.biopsych.2025.01.013
- Citations
- 3
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 2.73
Funders
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Sorbonne Université
- Institut pour la Recherche en Santé Publique