Genetic Variants of <i>GBP4</i>: Reduced Risks for Drug‐Induced Acute Liver Failure in Non‐Finnish European Population
Our study identified eight GBP4 missense variants linked to a lower risk of DIALF in the non-Finnish European population. The GBP4 protein, activated by interferon-gamma, plays a critical role in innate immunity. These findings suggest that GBP4 variants might influence immune and inflammatory responses in DIALF, though further studies are needed to elucidate the underlying mechanisms.
Authors
- Ruili Huang (ORCID: https://orcid.org/0000-0001-8886-8311)
- Jorge L. Rakela (ORCID: https://orcid.org/0000-0002-7088-9779)
- Raúl J. Andrade (ORCID: https://orcid.org/0000-0002-1565-0757)
- Minjun Chen (ORCID: https://orcid.org/0000-0002-6453-2351)
- Menghang Xia (ORCID: https://orcid.org/0000-0001-7285-8469)
- Bo‐Rong Pan (ORCID: https://orcid.org/0000-0001-9303-6464)
- Tsung‐Jen Liao
- Paul Hideyo Hayashi (ORCID: https://orcid.org/0000-0002-5371-1020)
- William M. Lee (ORCID: https://orcid.org/0000-0002-2783-5441)
- M. Isabel Lucena (ORCID: https://orcid.org/0000-0001-9586-4896)
- Jody A. Rule (ORCID: https://orcid.org/0000-0002-4019-372X)
- Guruprasad Padur Aithal (ORCID: https://orcid.org/0000-0003-3924-4830)
Institutions
- National Institutes of Health (US)
- National Center for Toxicological Research (US)
- Center for Drug Evaluation and Research (US)
- University of Nottingham (GB)
- WinnMed (US)
- National Institute for Health and Care Research (GB)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Nottingham Biomedical Research Centre (GB)
- Mayo Clinic in Florida (US)
- National Center for Advancing Translational Sciences (US)
- Andalusian Centre for Nanomedicine and Biotechnology (ES)
- Instituto de Investigación Biomédica de Málaga (ES)
- Universidad de Málaga (ES)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Liver International
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1111/liv.70011
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences