The fungal microbiota modulate neonatal oxygen-induced lung injury
These findings demonstrate that features of the initial intestinal fungal microbiome are associated with the later development of BPD in premature neonates and exert a microbiome-driven effect that is transferable and modifiable in murine models, which suggests both causality and a potential therapeutic strategy. Video Abstract.
Authors
- Kosuke Tanaka (ORCID: https://orcid.org/0000-0001-5436-6399)
- Viral G. Jain (ORCID: https://orcid.org/0000-0002-1897-6461)
- Teodora Nicola (ORCID: https://orcid.org/0000-0002-0815-6785)
- Kent A. Willis (ORCID: https://orcid.org/0000-0001-7338-0399)
- Isaac Martin (ORCID: https://orcid.org/0000-0002-4828-0369)
- Brian Halloran (ORCID: https://orcid.org/0000-0003-4259-4524)
- Luan D. Vu (ORCID: https://orcid.org/0000-0001-8493-1811)
- Tamás Jilling (ORCID: https://orcid.org/0000-0002-6200-3851)
- İbrahi̇m Karabayir (ORCID: https://orcid.org/0000-0002-7928-176X)
- Stephania A. Cormier (ORCID: https://orcid.org/0000-0002-6050-6172)
- Namasivayam Ambalavanan (ORCID: https://orcid.org/0000-0003-0731-9092)
- Oğuz Akbilgiç (ORCID: https://orcid.org/0000-0003-0313-9254)
- Brian M. Peters (ORCID: https://orcid.org/0000-0002-0445-2077)
- Jay P. Desai (ORCID: https://orcid.org/0000-0002-7072-2899)
- Mary Silverberg (ORCID: https://orcid.org/0000-0002-0857-2420)
- Ahmed Abdelgawad (ORCID: https://orcid.org/0000-0003-4723-5686)
- Erin D. Myers (ORCID: https://orcid.org/0000-0003-3939-8995)
- Charitharth Vivek Lal (ORCID: https://orcid.org/0000-0001-9071-4047)
- Laura Tipton (ORCID: https://orcid.org/0000-0002-5118-2671)
- Samuel J. Gentle (ORCID: https://orcid.org/0000-0003-0238-6472)
- Joseph F. Pierre (ORCID: https://orcid.org/0000-0002-4248-1290)
- Catrina T. White (ORCID: https://orcid.org/0000-0002-7154-8634)
- Ajay J. Talati (ORCID: https://orcid.org/0000-0002-7980-3679)
Institutions
- Pennington Biomedical Research Center (US)
- James Madison University (US)
- Louisiana State University (US)
- University of Wisconsin–Madison (US)
- University of Tennessee Health Science Center (US)
- University of Alabama at Birmingham (US)
- The University of Texas at San Antonio (US)
- Wake Forest University (US)
Publication Details
- Journal
- Microbiome
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s40168-025-02032-x
- Citations
- 5
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 7.59
Funders
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- Eunice Kennedy Shriver National Institute of Child Health and Human Development