Tumor-associated-fibrosis and active collagen-CD44 axis characterize a poor-prognosis subtype of gastric cancer and contribute to tumor immunosuppression
Our study identified a new subtype of gastric cancer, revealing that fibrosis is a critical mechanism driving immune suppression in gastric cancer and emphasizing the central role of the Collagen-CD44 signaling axis. The Collagen-CD44 signaling axis has the potential to serve as a novel therapeutic target for gastric cancer by enhancing immune cell-mediated tumor suppression. By combining it with immune checkpoint inhibitors (ICIs), it may improve the efficacy of immunotherapy for gastric cancer and offer new hope for treatment.
Authors
- Heng Mei (ORCID: https://orcid.org/0000-0001-7941-2443)
- Minghui Ji (ORCID: https://orcid.org/0000-0003-3399-9933)
- Chang Gao (ORCID: https://orcid.org/0000-0001-7825-0024)
- Yingqi Yang
- Xiaomeng Jiang (ORCID: https://orcid.org/0009-0001-3740-3351)
- Hongkai Yu (ORCID: https://orcid.org/0009-0002-8938-8939)
- Haohan Sun
- Luyao Wang (ORCID: https://orcid.org/0009-0004-5655-1650)
Institutions
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s12967-025-06070-9
- Citations
- 22
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 23.00