DLAT is involved in ovarian cancer progression by modulating lipid metabolism through the JAK2/STAT5A/SREBP1 signaling pathway
This study uncovers a novel DLAT/JAK2/STAT5/SREBP1 axis that reprograms lipid metabolism in OC, providing insights into metabolic vulnerabilities and potential therapeutic targets for OC treatment.
Authors
- Shen Luo (ORCID: https://orcid.org/0000-0002-1912-6741)
- Xin Wu (ORCID: https://orcid.org/0000-0003-0027-1110)
- Hui Wang (ORCID: https://orcid.org/0009-0005-6936-9281)
- Yue Yin (ORCID: https://orcid.org/0000-0002-9434-7827)
- Yan Liu (ORCID: https://orcid.org/0000-0003-4242-4840)
- Xiaomei Sun
- Ling Qiu
Institutions
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s12935-025-03656-7
- Citations
- 5
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.68