Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria
In this first multicenter validation study, four fulfilled HLH-2004 criteria and an HScore of 169 were suitable to diagnose secondary HLH, which will lead to rapid diagnosis and improved patient outcomes. Ferritin proved as a reliable HLH screening marker. Our results should be taken into account in clinical recommendations and in designing new studies.
Authors
- Peter Nyvlt
- France Debaugnies (ORCID: https://orcid.org/0000-0002-4607-7033)
- Olaf Neth (ORCID: https://orcid.org/0000-0001-5018-0466)
- Claudia Spies (ORCID: https://orcid.org/0000-0002-1062-0495)
- Lionel Galicier (ORCID: https://orcid.org/0000-0002-0360-7620)
- Patrick Heeren (ORCID: https://orcid.org/0000-0001-9356-2296)
- Carole Nagant (ORCID: https://orcid.org/0000-0001-9755-5069)
- Gunnar Lachmann (ORCID: https://orcid.org/0000-0003-2330-9839)
- Haowei Sun (ORCID: https://orcid.org/0000-0002-0205-9722)
- W. Ammouri (ORCID: https://orcid.org/0000-0002-0677-5275)
- Cornelia Knaak
- Yini Wang (ORCID: https://orcid.org/0000-0001-8545-2660)
- Nikhil Meena (ORCID: https://orcid.org/0000-0002-0225-1239)
- Insa Feinkohl (ORCID: https://orcid.org/0000-0002-0307-1862)
- Gritta Janka (ORCID: https://orcid.org/0000-0002-5397-3047)
- Frank M. Brunkhorst (ORCID: https://orcid.org/0000-0002-8132-8651)
- Paul La Rosée (ORCID: https://orcid.org/0000-0002-6758-7809)
- Juan San Martín (ORCID: https://orcid.org/0000-0003-4457-5124)
- Friederike S. Schuster (ORCID: https://orcid.org/0000-0001-5447-7929)
- Jae‐Ho Yoon (ORCID: https://orcid.org/0000-0002-2145-9131)
- Stefan Nierkens (ORCID: https://orcid.org/0000-0003-3406-817X)
- Zhao Wang (ORCID: https://orcid.org/0000-0003-1067-4589)
- Jia Yuan (ORCID: https://orcid.org/0000-0002-8142-6112)
- Thomas Schenk
Institutions
- Mohammed V University (MA)
- Université Libre de Bruxelles (BE)
- University of Alberta (CA)
- Witten/Herdecke University (DE)
- Universität Hamburg (DE)
- Centre Hospitalier de Luxembourg (LU)
- Capital Medical University (CN)
- Peking University (CN)
- Max Delbrück Center (DE)
- University Medical Center Utrecht (NL)
- Humboldt-Universität zu Berlin (DE)
- Centre Hospitalier Universitaire Brugmann (BE)
- University Medical Center Hamburg-Eppendorf (DE)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Beijing Anzhen Hospital (CN)
- Peking University People's Hospital (CN)
- Princess Máxima Center (NL)
- Instituto de Biomedicina de Sevilla (ES)
- Center for Translational Molecular Medicine (NL)
- Jena University Hospital (DE)
- Schwarzwald-Baar Klinikum (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Beijing Friendship Hospital (CN)
- Hospital Universitario de Fuenlabrada (ES)
- Hospital Universitario Virgen del Rocío (ES)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Hôpital de la Timone (FR)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Universidad de Sevilla (ES)
- University of Arkansas for Medical Sciences (US)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Journal of Internal Medicine
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1111/joim.20065
- Citations
- 22
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 38.94
Funders
- Charité – Universitätsmedizin Berlin
- Berlin Institute of Health