FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis
This proof-of-concept study demonstrates the potential of mRNA-based therapies delivering FGF21 and APOA1 in experimental AP. While individual treatments effectively reduced pancreatic injury, the APOA1-FGF21 fusion molecule did not exhibit superior activity. Liver-targeted LNP-mRNA administration may offer a promising approach for treating AP, leveraging endogenous production pathways for therapeutic proteins. Further research is warranted to elucidate the mechanisms underlying their therapeutic efficacy and optimize treatment regimens for clinical translation.
Authors
- Carlos L. del Rio (ORCID: https://orcid.org/0000-0002-9761-7888)
- María U. Latasa (ORCID: https://orcid.org/0000-0002-0878-1337)
- Nuria Ardaiz (ORCID: https://orcid.org/0000-0002-9168-553X)
- Celia Gomar (ORCID: https://orcid.org/0000-0001-7864-9481)
- Matías A. Ávila (ORCID: https://orcid.org/0000-0001-6570-3557)
- Jesús Urmán (ORCID: https://orcid.org/0000-0002-9806-9094)
- Amaya López-Pascual (ORCID: https://orcid.org/0000-0001-6091-8225)
- Roberto Escudero Barbero (ORCID: https://orcid.org/0009-0006-3209-5923)
- Paolo G.V. Martini (ORCID: https://orcid.org/0000-0002-0051-797X)
- Anne-Renee Graham
- Carmen Berasain (ORCID: https://orcid.org/0000-0001-7075-2476)
- Iker Uriarte (ORCID: https://orcid.org/0000-0001-5237-7799)
- Eva Santamaría (ORCID: https://orcid.org/0000-0003-0629-6175)
- Pedro Berraondo (ORCID: https://orcid.org/0000-0001-7410-1865)
- Antonio Fontanellas (ORCID: https://orcid.org/0000-0001-9279-7990)
- Maite G. Fernández‐Barrena (ORCID: https://orcid.org/0000-0003-0375-6236)
- María Arechederra (ORCID: https://orcid.org/0000-0002-4830-1924)
- Tiffany Palmer
- James E. Schultz
Institutions
- Catholic University of Ávila (ES)
- Moderna Therapeutics (United States) (US)
- Navarre Institute of Health Research (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s12967-025-06129-7
- Citations
- 4
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- Ministerio de Ciencia, Innovación y Universidades
- Ministerio de Sanidad, Consumo y Bienestar Social
- Moderna
- European Commission
- Fundación Científica Asociación Española Contra el Cáncer
- Ministerio de Ciencia e Innovación
- Gobierno de Navarra
- Dirección General de Industria, Energia y Proyectos Estrategicos S3, Gobierno de Navarra
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- European Social Fund