CircPRKD3-loaded exosomes concomitantly elicit tumor growth inhibition and glioblastoma microenvironment remodeling via inhibiting STAT3 signaling
This study provides a novel mechanism by which GDE-circPRKD3 relies on STAT3 signaling to remodel immunosuppressive TME and offers a potential RNA immunotherapy strategy for GBM treatment.
Authors
- Chaoshi Niu
- Mengyuan Jiang
- Wanxiang Niu (ORCID: https://orcid.org/0000-0002-2970-9473)
- Xiaoming Zhang (ORCID: https://orcid.org/0000-0002-0033-0400)
- Shanshan Hu (ORCID: https://orcid.org/0000-0001-9042-3194)
- Ce Zhang (ORCID: https://orcid.org/0000-0002-4445-9572)
- Minglong Yang (ORCID: https://orcid.org/0000-0001-5725-8481)
- Ben Xu (ORCID: https://orcid.org/0000-0002-1557-0052)
Institutions
- University of Science and Technology of China (CN)
- Anhui University (CN)
- Hefei University of Technology (CN)
- Anhui Provincial Center for Disease Control and Prevention (CN)
- Anhui Provincial Hospital (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1093/neuonc/noaf019
- Citations
- 13
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 10.48