Advancements in Aquasomes‐Based Topical Drug Delivery for Enhanced Dermatological Treatments

ABSTRACT Background Aquasomes are novel nanoparticulate carriers that are applied topically to deliver medications, particularly in dermatology. These carriers are composed of a polyhydroxy oligomer layer covering a solid core, usually composed of ceramic or calcium phosphate. The bioactivity of delicate molecules, such as proteins, peptides, and genetic material, is preserved by this special structure. Aquasomes are especially useful for improving the stability, bioavailability, and controlled release of therapeutic substance, while reducing systemic absorption and unfavorable side effects. Method The efficacy of aquasomes in treating dermatological conditions has been the subject of recent research. Their capacity to administer anti‐inflammatory medications for ailments like acne, psoriasis as well as wound healing has been investigated. Additionally, research has looked into how well aquasomes can help bigger molecules pass through the epidermal barrier. The effectiveness, safety, as well as skin irritation of aquasomes have been evaluated through comparisons with traditional topical formulations. Results Aquasomes were less irritating and more effective than conventional topical applications for localized skin conditions. Furthermore, a 2024 study showed that aquasomes improved the ability of big molecules to pass through the epidermal barrier, which made them appropriate for noninvasive medication administration. Conclusion In the fields of dermatology and cosmetics, aquasomes hold great promise as a topical treatment delivery system. With fewer adverse effects, they provide improved stability, bioavailability, along with controlled drug release. The therapeutic value for dealing with skin conditions and enhancing cosmetic formulations will be maximized with continued research to optimize their properties.