Disparities in outcomes of pancreatic cancer hospitalizations: A ten-year trend study.

683 Background: Pancreatic cancer is the third leading cause of cancer mortality in the United States with 51,750 estimated deaths from Pancreatic cancer in 2024. Demographic variations have been reported with Pancreatic cancer. Our aim was to identify trends in demographic-specific disparities in inpatient pancreatic cancer outcomes. Methods: This is a retrospective longitudinal trends study using the Nationwide Inpatient Sample (NIS) database (2010-2019). We identified hospitalizations with pancreatic cancer using ICD-9 and ICD-10 codes. We highlight disparities in mortality outcomes stratified by age, gender and race. Results: There were 992,550 hospitalizations of pancreatic cancer patients between 2010 and 2019. Over the period, the mean age at hospitalization was similar at 68 years (P = 0.006). A majority of the admissions were elderly patients (≥65 years) identifying as males and Caucasians (P < 0.01). Most patients had Medicare and were in large and urban teaching hospitals (P < 0.001). Over the decade, there was an overall decline in inpatient mortality, from 8.2% in 2010 to 7.1% in 2019 (P trend = 0.004). Amidst the age subgroups, only the elderly patient group experienced a significant decline in mortality rate (8.8% to 7.3%; P trend = 0.004). The young adult population (<45 years) had a trend towards increasing mortality rate, but it was not significant (P trend= 0.139). On gender subgroup analysis, only males had a significant decline in mortality rate (P trend= 0.003). On racial subgroup analysis, only Caucasians had a significant decline in mortality trend (P trend= 0.004) during the study period. Conclusions: There was an overall improvement in the mortality outcome of pancreatic cancer hospitalizations. On sub-group analysis, significant decline in mortality over the decade were seen only in elderly, male and Caucasian patient groups. Targeted research is needed in understanding the root causes of these disparities in pancreatic cancer outcomes and develop effective intervention to bridge this gap. Trends in mortality outcomes of pancreatic cancer hospitalizations by demographic subgroups. Mortality rate, % 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 P- Trend value Overall 8.21 7.94 7.85 7.70 7.73 7.68 7.46 7.87 7.47 7.14 0.004 Young (<45 years) 4.45 5.55 5.23 6.08 6.27 5.32 3.63 6.84 6.95 6.35 0.14 Middle-aged (45- 64 years) 7.55 7.24 7.74 7.32 7.03 6.99 7.62 6.80 6.74 6.91 0.06 Elderly (>65 years) 8.81 8.44 8.04 8.00 8.22 8.19 7.54 8.48 7.87 7.29 0.004 Females 7.72 7.32 7.23 7.15 6.99 7.31 6.72 7.38 7.01 6.87 0.08 Males 8.67 8.57 8.44 8.22 8.44 8.04 8.13 8.32 7.90 7.38 0.003 Whites 7.94 7.49 7.48 7.39 7.81