The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice
Our data suggest that ABCA7 transporters regulate the communication between microglia and astrocytes through the NLRP3 inflammasome and the release of proinflammatory cytokines. This regulation implicates ABCA7 as a key driver ultimately involved in the persistence of the inflammatory response observed in AD.
Authors
- Iván Eiriz
- Thomas Brüning (ORCID: https://orcid.org/0000-0002-7060-6564)
- Jens Pahnke (ORCID: https://orcid.org/0000-0001-7355-4213)
- Pablo Bascuñana (ORCID: https://orcid.org/0000-0003-2186-8899)
- Irene Santos‐García (ORCID: https://orcid.org/0000-0002-6266-9530)
- Mirjam Brackhan (ORCID: https://orcid.org/0000-0002-0753-6292)
- Maria Pia Villa (ORCID: https://orcid.org/0000-0001-9394-4323)
Institutions
- Latvia University of Life Sciences and Technologies (LV)
- Oslo University Hospital (NO)
- Tel Aviv University (IL)
- University of Oslo (NO)
- Hospital Clínico San Carlos (ES)
- Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
- University of Lübeck (DE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s13195-025-01673-2
- Citations
- 12
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 24.08
Funders
- Technology Agency of the Czech Republic
- European Commission
- Deutsche Forschungsgemeinschaft
- Universitetet i Oslo
- Norges Forskningsråd
- Helse Sør-Øst RHF