USP11 promotes autophagy to attenuate LPS-induced oxidative stress in lung epithelial cells by stabilizing FOXO1 levels
This study identifies USP11 as a key regulator of FOXO1 and autophagy in ALI. The stabilization of FOXO1 through USP11 represents a promising therapeutic strategy for reducing oxidative stress and inflammation in ALI, warranting further clinical investigation.
Authors
- Y. Zhang (ORCID: https://orcid.org/0009-0004-7261-7955)
- Junhao Xie (ORCID: https://orcid.org/0000-0002-1935-1842)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-2488-5021)
- Wei Zhan (ORCID: https://orcid.org/0000-0002-5404-4581)
- Jiaxing Liu (ORCID: https://orcid.org/0000-0001-9691-8470)
- Tai Xiang (ORCID: https://orcid.org/0009-0007-4375-9956)
- Q. Xu
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.bbrc.2025.151368
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35